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It simultaneously activates three crucial receptors involved in appetite regulation and glucose metabolism: GIP (Glucose-Dependent Insulinotropic Polypeptide) Receptor: GIP is an incretin hormone that stimulates insulin release in response to glucose and may also have effects on fat metabolism

Importantly, serum B12 levels can be misleadingly normal or even elevated in chronic liver disease due to increased levels of binding proteins (such as haptocorrin) and reduced clearance, meaning that total B12 measurements may not accurately reflect tissue B12 status or functional deficiency

Adults across a wide age range use B12 support for different reasons

The normality of the data distribution was assessed using the Kolmogorov-Smirnov test