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This assertion is based on the clinical observation that patients with Hashimoto's thyroiditis often develop myxedema, and the knowledge that patients with myxedema due to atrophy of the thyroid have a high incidence of TG Ab in their serum

This suggests that future research should focus on identifying the specific bioactive components within EVs that are responsible for modulating cholesterol metabolism, paving the way for targeted therapeutic strategies to address lipid-related disorders

Similar to SIRT3, SIRT6 is also activated by fucoidans

Patients with untreated primary hypothyroidism showed blunted GH responses to both GHRH and GHRP-6, though the mechanism differed between the two