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In damage models where connective tissues have torn or degenerated, this peptide helps up-regulate early EGR-1 (Early Growth Response 1) gene expression

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NAC group (rats were injected intraperitoneally with MTX on day 7 plus NAC 500 mg/kg/day throughout the experiment by oral gavage, plus Kolliphor EL from day 1- day 10) (Li et al., 2018