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LRP5 primarily encodes the transmembrane LDL receptor, which facilitates Wnt protein signaling and participates in other processes, including skeletal development

However, there are also studies suggesting that CPS1 is upregulated, and CPS1 expression is significantly upregulated in poorly differentiated HCC relative to moderately and highly differentiated HCC, suggesting that CPS1 is associated with the degree of tumor differentiation(Wang et al

An NDA filing is expected in late 2026 or early 2027, with FDA approval potentially in late 2027 or the first half of 2028