tirzepatide blood pressure reduction for maintenance of bodyweight in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial Comparison of weight and blood

In one study with over 33,000 participants, those taking semaglutide had a much lower risk of opioid overdose compared to those who didn't take it, suggesting it is safe to use alongside treatments for opioid addiction

Class B1 GPCRs bind their peptide agonists via a two-domain model, whereby the C-terminus of the peptide interacts with the receptor extracellular N-terminal domain (ECD) promoting an affinity trap that enables the engagement of the N-terminus of the peptide with the receptor transmembrane domain (TMD), with interactions with the TMD required for receptor activation 9

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Participants were asked to complete patient-reported outcome measures (PROMs) at baseline and after 1 month, 3, 6, and 12 months, as well as to report any adverse events