The documented handling is to take it soon if several days remain before the next scheduled dose, or skip it otherwise never double up, because two doses close together stacks the incretin effect and reliably provokes GI symptoms
Patients with certain genetic variants in the GLP1R gene (such as rs6923761) may experience stronger gastric effects from semaglutide, potentially increasing the risk of Synthroid absorption issues
Any weight you give that endorsement should account for that gap
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