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The M6 (Macrovascular & Microvascular Morbidity and Mortality) study followed 3,932 adults with obesity and type 2 diabetes treated at Cleveland Clinic for up to 10 years : 1,657 had metabolic surgery (sleeve gastrectomy or gastric bypass) and 2,275 used GLP-1 receptor agonists (e.g., liraglutide, dulaglutide, exenatide, semaglutide, tirzepatide)

natator roe were, though not statistically significant, with a p value of 0.326 necessitating larger-scale study

Adherence to the recommended low-fat diet (30% of calories from fat) is the most effective way to minimize these effects

however, it is unclear whether oxidative stress is a cause or result of hypertension