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Overall, across the two repeat experiments for Cagri and CagriBB bound to the CTR, the conformational equilibrium between the bypass vs CT-like state was similar, suggesting that the salt bridge/ionic lock is sufficient to preferentially stabilize the bypass conformation at CTR (Supplementary Fig

While copper is an essential trace mineral required for iron metabolism and neurotransmission, excessive systemic accumulation carries a very real risk of acute copper toxicity

This is not painful either, but may come as a surprise