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The 2-year limit exists because clinical trials hadnt extensively studied outcomes beyond this duration when NICE made its recommendation, and because of cost-effectiveness modelling
In Class 1, HDACs 1, 2, 3, and 8 are clustered based on their similarity to yeast transcriptional regulator, reduced potassium deficiency 3 (Rpd3) (Wiech et al., 2009) while HDAC 8 is found to be expressed in smooth muscle and plays a key role in muscle contractility
There is also notable whitespace in formulating for demographic groups that are underserved by current GLP-1 therapies, such as older adults, men with visceral fat, and individuals with prediabetes
However, those with specific medical history like thyroid cancer or pancreatitis must discuss alternatives with their provider to achieve healthy outcomes
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