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A behavioural neuroscientist by training, Sophie has spent 30 years working at the intersection of medical research, pharmacology, technology and patient communication across the pharmaceutical industry, health technology and charity sectors
Non-anatomical factors, such as neuromuscular control of the airway and systemic inflammation, also play a significant role in the condition
The gut peptides signaling to the hypothalamus act via the ARC to mediate the appetite stimulation (+) effect through the activation of neurons containing neuropeptide Y (NPY) and Agouti-Related Peptide (AgRP) or appetite-inhibitory effects (-) via neurons containing the preopiomelanocortin (POMC)-derived alpha-melanocyte stimulating hormone (alpha-MSH) and cocaine and amphetamine regulated transcript (CART) peptide to hunger centers in the LHA, the satiety center in PVN in the medial hypothalamus (16)
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