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The FDA prescribing information for Wegovy includes a warning about suicidal thoughts and behaviors, though a causal relationship has not been established

The analysis found that: At 12 months, Omada members largely maintained their weight at GLP-1 discontinuation, with an average 0.8% weight change At 12 months, 63.2% of members maintained or continued to lose weight At 6 and 9 months, Omada members demonstrated 0.03% and 0.6% average weight change, respectively These findings suggest that Omada can play an integral role in supporting members during important transitions in their GLP-1 journey, including helping members maintain their weight well after GLP-1 discontinuation.

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Future studies should aim to elucidate the mechanisms underlying these contradictory observations and identify the specific conditions under which GLP-1RAs might exert detrimental effects on the CNS