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It remains, however, a modeling rationale, not evidence that any particular frequency is safe or produces any particular outcome in a living subject

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Primary outcome (VTE) Pooling Ueda 2018, Patil 2023, and the head-to-head arm of Tsai 2023 gave HR 1.02 (0.841.23), indicating no clear difference in VTE risk between classes [22, 24, 25] (Fig

pre- and post-operative treatment, when requirements are increased as in fever, severe burns, increased metabolism, pregnancy, gastrointestinal disorders interfering with intake or absorption of vitamins, prolonged or wasting diseases, alcoholism and where other deficiencies exist