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Senolytic vaccines from the central and peripheral tolerance perspective

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Moreover, in TNF--stimulated ECs, the copper-dependent ATOX1-TRAF4 interaction promotes nuclear translocation and initiates ROS-dependent inflammatory responses, solidifying this axis as a promising therapeutic target [45]

Examples include semaglutide (brand names Ozempic and Wegovy), tirzepatide (brand name Mounjaro), and liraglutide (brand names Victoza and Saxenda)