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-KG acts as a cofactor for epigenetic enzymes such as TET dioxygenases and Jumonji histone demethylases, directly influencing the DNA methylation status of the Foxp3 locus (112)

It was shown that paraoxonase-1 (PON1) and arylesterase activity were decreased (the arylesterase activity linked to PON1 is known to protect lipoproteins from oxidation) and there was also a decrease in the total antioxidant status

Hyperchromic macrocytic megaloblastic anemia (pernicious anemia, Biermer's anemia, Addison's anemia - these are maturation disorders of the red blood cells)