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In addition, this release is mediated as a result of changes in pH through the uptake of H + by ion channels such as polycystic kidney disease proteins 1 like 3 and 2 like 1 (PKD1L3, PKD2L1), inward rectifying K + channel (KIR2.1) and the epithelial Na + channel (ENaC) [4142434445]

Molecular pharmacology 78, 456465, doi: 10.1124/mol.110.065664 (2010)

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5.4 New Treatment Approches for DPN Recent advancements in DPN treatment focus on both symptom management and addressing underlying nerve damage through innovative pharmacological, non-invasive and regenerative approaches