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doi: 10.3389/fmed.2026.1763185 Received 08 December 2025 Revised 20 January 2026 Accepted 26 January 2026 Published 12 February 2026 Volume 13 - 2026 Edited by Jianbin Zhang, Dalian Medical University, China Reviewed by Theodoros Androutsakos, National and Kapodistrian University of Athens, Greece Feng Zhang, Nanjing University of Chinese Medicine, China Updates Copyright 2026 Lu and Yang

The protein bands from Western blots were quantified using Quantity One software (Bio-Rad)

Oral orfoglipron, as opposed to peptide-based oral semaglutide, can be taken without regard to food timing