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The supramammillary nucleus, located in the hypothalamus, is a new candidate that appears to be responsible for GLP-1 mediated anxiety effects because selective activation of GLP-1Rs in this nucleus by exendin-4 resulted in intensified anxiety-like behavior both in male and female rats

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While there is no official link between tirzepatide and allodynia, any new neurological symptoms warrant clinical assessment to determine the underlying cause

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