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Risk of bias using Cochrane risk-of-bias tool for randomized trials-Kosibord, 2023

2 CKD confirmatory secondary endpoints Significant 18% RRR of MACE with Ozempic 2 For adults with T2D and CKD, for a confirmatory secondary endpoint: Time to first occurrence of MACE (CV death, nonfatal MI, or nonfatal stroke) vs placebo when both were added to standard of care 1,2 Time to first MACE 1-3,w-z 1-3,w-z w Cumulative incidence estimates are based on time from randomization to first EAC-confirmed MACE with non-CV death modelled as a competing risk using the Aalen-Johnson estimator

A.TangB.SoragniE.BurnettR.et al

Long-term use at very high doses and interactions with certain medications (particularly nitroglycerin and potentially anticoagulants) warrant provider guidance