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deviations, investigations and out-of-specification handling

The main adjustments involve: Switching from vial-and-syringe to a pre-filled pen device Losing the B12 component (you may need separate B12 supplementation) Adjusting to fixed dose increments instead of flexible dosing Potential insurance/cost changes Discuss transition planning with your provider proactively rather than waiting until your compounding pharmacy can no longer fill your prescription

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References Ahmed, A., & Clarke, J