Researchers exploring peptides for menopause weight loss or peptides for fat loss should be aware that rapid weight loss increases gallstone risk regardless of the method used
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upon observing 5 cases of longitudinal pachymelanonychia, in which the histological findings were of acanthoma of the nail matrix producing onychocytes.49 All cases described thus far have occurred on the fingers, as a single lesion, characterized by localized thickening of the nail plate (pachyonychia), longitudinally brownish melanonychia (variable pigmentation from mild to intense), and subungual keratosis at the free edge.38,4952 Only one case was described as a hypopigmented variant, in which xanthonychia was observed instead of melanonychia.53 A well-defined longitudinal melanonychia and subungual keratosis at the free edge/hyponychium are better visualized with dermoscopy (Fig
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