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Such cross-contamination or additional stress to the sample may occur by applying too much pressure during tissue infiltration or due to microscope properties (strong light source, high temperature, lack of oxygen, water stress), but likewise during organelle isolation or fractionation (Zechmann 2014)

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The higher permeability in the micro device derives from increased perfusate diffusion from the side channels over the same time

Liver regeneration The liver is the main source of circulating insulin-like growth factor I, accounting for ~75% of circulating IGF-I levels secondary to the GH stimulation on hepatocytes[23, 46, 47]