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4-Hydroxy-2-nonenal, a lipid peroxidation product, as a biomarker in diabetes and its complications: challenges and opportunities

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Diarrhea occurs in 13-17% of patients taking tirzepatide for type 2 diabetes and 19-24% of those using it for weight management, with higher rates at increased doses

GSH and necroptosis Necroptosis is a regulated form of necrotic cell death characterized by activation of RIPK3 and mixed lineage kinase domain-like pseudokinase (MLKL), with receptor-interacting serine/threonine kinase 1 (RIPK1) participating in many, but not all, necroptotic contexts