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This detection prompts the production of antimicrobial peptides and pro-inflammatory cytokines (e.g., IL-1, IL-6, IL-10, TNF-), immune cell infiltration, and the upregulation of apoptosis-related proteins such as BAX, caspase-3, and caspase-8, which collectively impair skin barrier functionality through mitochondrial-mediated apoptosis [41]
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