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For instance, experiments involving the co-incubation of Caco2-cells with Enterococcus faecalis or Mitsuokella multiacidus bacterial supernatants have shown a significant decrease in GLP-1 mRNA abundance 73

PT-141 (Bremelanotide) PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist studied for its role in sexual arousal and central libido signaling

Research published in the journal Diabetes, Obesity and Metabolism confirms that GLP-1 receptor agonists reduce intestinal transit time through direct action on smooth muscle cells lining the gut wall