2 (terms were searched in articles abstract and keywords), 621 co-occurrences were recorded, clustered into four categories namely, 194 items for the red cluster (e.g., bioavailability, peptide, peptides, functional food, chemistry), 187 items for the green cluster (e.g., animals, metabolism, intestinal flora, nutrition), 154 items for the blue cluster (e.g., drug delivery systems, oxidative stress, drug effect flavonoid), and 86 items for the yellow cluster (e.g., in vivo study, enzyme activity, anti-bacterial agents, corona virus)
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The study was designed to show that overall survival with pemetrexed was non-inferior to docetaxel, as the major efficacy outcome measure, and that overall survival was superior for patients randomized to pemetrexed compared to docetaxel, as a secondary outcome measure
TNF- was measured in the DRG and SC tissues during phases 1 and 2