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Fatigue that persists beyond 46 weeks, worsens despite supplementation, or significantly limits daily function warrants a provider conversation about dose reduction, temporary pause, or alternative therapy

To view or add a comment, sign in RBM20 truncating variants were associated with reduced lifetime penetrance and milder disease in #DilatedCardiomyopathy compared to pathogenic RBM20 or titin variants, suggesting a low-effect role in arrhythmogenic cardiomyopathy

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Table 4 Pathogenic mechanism of gut microbiota and metabolites in cardiometabolic diseases