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66 Post-herpetic neuralgia affects one in five patients with HZ and, whilst most patients fully recover within 1 year, for some symptoms can persist for years or may be permanent

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Lastly, despite PDE5i treatment has been proven a cost-effective therapeutic strategy, compared to no treatment [62], the relatively high cost of a chronic treatment with some reference/equivalent pharmaceutical formulations belonging to this category of drugs might still represent a limitation for patients with economic constraints, by contributing to treatment discontinuation