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However, in a large proportion of patients, the disease progresses and the curvature of the penis continues to worsen

Tumor-associated macrophages induce epithelial-mesenchymal transition and promote lung metastasis in breast cancer by activating the IL-6/STAT3/TGM2 axis

Nature 535 (7610), 153158 (2016)

Moreover, our cell-based activity assays showed that the HGF with mutations that disrupt either K1SEMA or SPHSEMA interaction no longer activated c-MET, but the HGF with mutations that disrupt either NSEMA, K2SEMA, or K3SEMA interaction still exhibited partial activity, suggesting that the K1SEMA and SPHSEMA interfaces are more critical for HGF-induced c-MET activation than any other interfaces