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There was a significant average paired fold change in the levels of several GPs 1 week after 4-week intermittent fasting compared with the levels at the end of 4th week during 4-week intermittent fasting (Supplementary Table S3)

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Future investigations must elucidate the molecular mechanisms underlying NMDR patterns, particularly focusing on hormone receptor binding kinetics, metabolic clearance rates, and compensatory cellular responses that may explain these complex relationships