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Patients with Renal Impairment Exposure parameters, AUC0-t and AUC0-inf, were approximately 13%-15%, 34%-35%, and 86% 96% higher for patients with mild, moderate, and severe renal impairment, respectively, as compared to patients with normal renal function [ see Dosage and Administration (2.4)]

The Orange Book lists approved small-molecule drug products and records the patents brand manufacturers have submitted for listing under Hatch-Waxman, along with regulatory exclusivities

Effect of the interruption of ggt and pepT on GSH degradation Previous studies have indicated that GSH is significantly degraded close to the end of the fermentation process, resulting in a lower GSH production level