tirzepatide peter attia Could GLP-1s impact aging and cognitive health? Peter Attia Leaving CBS News

Our previous work has demonstrated a role of DPP-4 non-enzymatic function in regulating dendritic cell (DC)/macrophage-mediated adipose tissue inflammation in obesity (64)

But even as access expands dramatically, new global evidence is raising concerns about the risks associated with discontinuing these therapies casting a shadow over what otherwise appears to be a watershed moment for patients

The mechanism of benefit appears to go beyond weight loss alone

Direct binding of eNOS to the scaffolding domain of Cav-1 is a well-accepted mechanism to repress eNOS activity that is associated with endothelial dysfunction and cardiovascular disease 39,40