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Similarly, a number of early-onset familial AD mutations display a more aggressive disease course and a greater propensity for A to form soluble oligomeric A aggregates (Ferreira and Klein, 2011

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However, in contrast to simple obesity, where GH is low and IGF-I within normal range (89), subjects with MASLD demonstrate variable changes in the GH/IGF-I axis depending on disease severity (121123) ( Table 1 )