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The total number of proteins that bind calcium is beyond the scope of this discussion but several important examples of intracellular Ca 2+ -binding proteins include the calmodulins, calcineurins, calbindins, and troponins, whereas important extracellular Ca 2+ -binding proteins include the coagulation factors [II (prothrombin), VII, IX, X, protein C, protein S] and the cell-cell communication/adhesion proteins of the cadherin family