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Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin dependent diabetes mellitus

By adding L-theanine to the drinking water of cirrhotic rats established by carbon tetrachloride, it was found that L-theanine inhibited the expression of NF-B, downregulated the pro-inflammatory cytokines (e.g., IL-1 and IL-6), and profibrotic mediators (e.g., transforming growth factor and connective tissue growth factor), and promoted the expression of anti-inflammatory cytokine IL-10 and fibrinolytic enzyme metalloproteinases-13 (85)

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For tirzepatide specifically, non-oral contraception or additional contraceptive precautions are recommended for 4 weeks after starting treatment and after each dose increase