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Low adiponectin levels are associated with both muscle atrophy and accelerated atherosclerosis Thus, the waning of anabolic hormonal support creates a shared environment of vulnerability, predisposing to the parallel progression of muscle wasting and vascular sclerosis (131, 132), highlighting another dimension of the dysregulated endocrine network in aging (131)

Elective surgery has also long been used as a paradigm of the stress response in humans (188-190): the magnitude of cortisol rise correlates positively with the severity of surgery (191)

Pigmentation of NAM typically involves more than two-thirds of the nail plate, while that of benign melanonychia shows an involvement of less than one-third

These findings align with those of pooled analyses from liraglutide phase 2/3 trials in obesity 171 and retrospective case-control studies in T2DM