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In combination with insulin (with or without metformin), sitagliptin provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo (Table 14)

Also, age is a factor

Folic Acid and Methylation Myths: Facts, Fallacies and What the Evidence Suggests If you have spent any time reading about folic acid, methylfolate, MTHFR or methylation, you have probably come away with more questions than answers