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These functions position oligodendrocytes not only as structural allies, but also as sensors and effectors that stabilize neuronal function across fluctuating energetic demands

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However, in an experimental model of encephalomyelitis, melatonin has been shown to upregulate expression of IL10 ( Melatonin has been found to alleviate mitochondrial dysfunction and to preserve myelin by supporting remyelination in an experimental model of multiple sclerosis (Tiong et al., 2019)

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