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Certain patient populations may potentially be more susceptible to heart rate changes: Patients with pre-existing cardiovascular conditions may notice heart rate changes more readily Individuals taking other medications that affect heart rate (such as sympathomimetics, decongestants, or certain antidepressants) may experience effects on heart rate Those with underlying medical conditions may have altered responses Patients who are dehydrated or experiencing gastrointestinal side effects may have temporary heart rate elevations The timing of heart rate increases can vary

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Room temperature is acceptable only for short periods

doi: 10.1016/j.neuroscience.2019.02.020