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One way that regulatory agencies monitor the safety of drugs post-approval is through systems where patients and doctors can voluntarily report adverse events possibly related to a drug or medical device

The average starting weight for both groups was ~232 lbs.* *Results are from a 68-week medical study of adults with obesity (BMI 30) and adults with overweight (BMI 27) who also had weight-related medical problems including high blood pressure or high cholesterol

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(Wegovy is already available on the NHS to help with weight management and for people with type 2 diabetes.) The exact mechanism through which semaglutide delivers cardiovascular benefits is not known, but may include the drugs positive impacts on blood sugar, blood pressure, and inflammation, as well as direct effects on the heart muscle and blood vessels