Research has characterised Semaglutides beta cell trophic biology in isolated islet models, beta cell lines, and rodent diabetes models , examining sustained caspase inhibition and Bcl-2 family upregulation protecting against glucolipotoxicity-induced beta cell death under chronic GLP-1R occupancy, proliferation rate increases and beta cell mass preservation in Semaglutide-treated diabetic and pre-diabetic rodent models, and the temporal dynamics of beta cell trophic responses to sustained versus episodic GLP-1R stimulation
Lots of this evidence seems quite promising, but some of it is a bit more concerning," he explains
Garca de Lucas MD, Caballero I, Fernndez-Garca JC, Domnguez-Rodrguez M, Moreno-Moreno P, Jimnez-Milln A, Botana-Lpez M, Avils B, Merino-Torres JF, Soto A
Dis Model Mech