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They are becoming, steadily, an established feature of how obesity is treated and the conversation is shifting accordingly, from the drama of early results to the less telegenic business of what comes next

However, long-term pharmacotherapy is required to maintain weight loss and cessation or withdrawal from therapy leads to weight regain even with continuing lifestyle intervention [4]

Nature 555 (7694), 121125

Preliminary studies in patients with T1DM and T2DM have shown that diabetes increases the urine ratio of lactobionate, and this may reflect the metabolic process of mitochondrial oxidation to glycolysis, which is reversed by SGLT2 inhibitors (Nespoux and Vallon, 2020)