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Activated Parkin ubiquitinates outer mitochondrial membrane proteins including Mfn1, Mfn2, Miro1, and VDAC1 (Tanaka et al., 2010), followed by PINK1-mediated phosphorylation of these ubiquitinated substrates to amplify polyubiquitin chain signaling (Harper et al., 2018)
coli was improved by the modification of metabolic pathways, including the reduction of l-cysteine degradation, manipulation of the glucose storage pathway, and elimination of the biological degradation of GSH
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They reduce mitochondrial oxidative damage by restricting mitochondrial ROS generation and increasing mitochondrial antioxidant systems such as mitochondrial SOD
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