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These findings indicate potential pathways through which incretin therapy may: Stimulate bone formation by activating osteoblasts Inhibit bone resorption via osteoclast suppression Influence calcium and phosphate homeostasis Together, these mechanisms offer biologic plausibility that GLP1 RAs could help preserve bone strength

For instance, allergen exposure in an asthma mouse model led to microglial cell activation, stimulation of pro-inflammatory cytokine expression, and damaging structural changes in the same brain regions associated with dementia and Alzheimers disease (AD) [38, 44]

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doi: 10.1016/S2213-8587(18)30024-X 23 FlintARabenAAstrupAHolstJJ