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NAD + can be administered via intravenous (IV) , intramuscular (IM) , or subcutaneous (SC) injection

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The gastrointestinal tract plays a key role in Mn uptake, mediated by metal transporters, and these transporters can also contribute to Mn excretion via the gastrointestinal tract and the hepatobiliary system (Mercadante et al., 2019

Individuals may be genetically predisposed to an attenuated intestinal barrier either by the expression of abnormal structural components, for example, those involved in TJ protein complexes that modulate paracellular transport across the epithelium (Mu et al