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This is based on the traditional lock-and-key principle (similar to that used to describe how enzymes catalyse reactions with their substrates) in which protein-based receptors in our noses match certain molecular shapes [Gaillard et al ., 2004]

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In contrast to the lead candidate described above, GQB47810 and neuromedin C, exhibited lower GLP-1R agonistic activity (Figure cAMP)

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