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Safety considerations warrant discussion , particularly regarding gastrointestinal side effects that might affect medication adherence or nutritional status

A personal history of stroke or a prior deep vein thrombosis also puts you at higher risk

In a systematic review article that included 40 clinical trials, tirzepatide at 15 mg ranked first in terms of HbA1c reduction rate, compared to other GLP-1RA-based strategies, and even those including insulin

The first GLP-1 RA , exenatide (Byetta) was first approved by the FDA in 2009 as a twice-daily injectable, intended to be taken within an hour of morning and evening meals