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In fact, folic acid in particular can be problematic for anyone with an MTHFR mutation

The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms

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But if left untreated, it may cause the following symptoms: Weakness, tiredness, or lightheadedness Lack of energy A decline in your mental abilities, such as memory and focus A painful and red tongue (glossitis) Mouth ulcers Pins and needles (paraesthesia) Disturbed vision Irritability Causes of Vitamin B12 deficiency