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Astrocytic alterations have also been implicated in SCZ, with reports of changes in astrocytic density, morphology, and the expression of markers such as glial fibrillary acidic protein (GFAP), aquaporin-4 (AQP4), S100, glutaminase, thrombospondin-1 (TSB-1), and excitatory amino acid transporter 2 (EAAT2

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Weight loss during this phase typically accelerates to 1 to 2 pounds per week

Effects manifest gradually : Weeks 1-2 : better energy during workouts, less post-workout fatigue Weeks 2-4 : improved recovery, first signs on waist circumference Weeks 4-8 : measurable improvement in endurance and fat loss Weeks 8-12 : full effects on body composition and performance Muscle saturation takes several weeks, which is why long-term courses are important (8-12 weeks minimum)