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Reduces glucagon secretion: glucagon is another hormone produced by the pancreas that has the opposite effect of insulin, increasing blood sugar levels, for instance, when the body is fasting

For the subgroup analysis of the time to the first occurrence of the main 5-component composite endpoint, the pre-specified Cox regression model also included an interaction between treatment group and the subgroup of interest, with the interaction P values evaluated using a score test

This personalized approach supports safe administration and helps align the treatment with realistic, achievable outcomes rather than a one-size-fits-all regimen