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While its safety profile was consistently favorable, the largest Phase IIb trial failed to show statistical significance for weight loss, and commercial development was halted in 2007.[2] Despite this, interest in AOD-9604 has continued in the compounding pharmacy and integrative medicine space, particularly given its safety data, its lack of IGF-1 stimulation, and emerging research around joint health

Thus, genomic human tumor data (TCGA data (cBioPortal)) demonstrate that at least one allele of NF1 and SUZ12 are codeleted/mutated in 24% of melanomas

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